Author/Authors :
Fereidooni, H Department of Physiology - Fars Science and Research Branch Islamic Azad University, Shiraz , Azarpira, N Transplant Research Center - Stem Cell Research Institute - Shiraz University of Medical Sciences, Shiraz , Yaghobi, R Transplant Research Center - Stem Cell Research Institute - Shiraz University of Medical Sciences, Shiraz , Vahdati, A Department of Physiology - Shiraz Branch Islamic Azad University, Shiraz , Malek-Hoseini, S. A Transplant Center - Shiraz University of Medical Sciences, Shiraz
Abstract :
Background: Interleukin-28 (IL-28B) rs12979860 C/T polymorphism is a known predictor of sustained
virological response after antiviral treatment in hepatitis C. IL-28B affects the innate immune system as
well as intrahepatic expression level of interferon-stimulated genes.
Objective: To investigate the effect of recipient IL-28B polymorphism on occurrence of acute rejection
after liver transplantation.
Methods: 140 liver allograft recipients were selected. Acute rejection episodes were recorded in 39 patients
(AR group); the remaining had normal graft function (non-AR group). 70 normal subjects were also
studied as the control group. The IL-28B rs12979860 was genotyped through PCR-RFLP method.
Results: No significant difference was found between AR and non-AR groups in terms of genotype and
allele frequency. However, the CC genotype was significantly (p<0.001) more frequent in patients than in
the control group; the C allele variants increased the risk of end-stage liver disease (OR: 2.60).
Conclusion: Liver damage in association with the carriage of IL-28B C allele is associated with a higher
likelihood of developing cirrhosis.
Keywords :
Liver transplantation , Rejection , Interleukin , IL-28B polymorphism
