Author/Authors :
Bayat, M Craniomaxillofacial Research center - Tehran University of Medical Sciences, Tehran , Garajei, A Oral and Maxillofacial Surgery Department - School of Dentistry -Tehran University of Medical Sciences, Tehran , Afshari Pour, E Oral and Maxillofacial Surgery Department - School of Dentistry -Tehran University of Medical Sciences, Tehran , Hasheminasab, M Oral and Maxillofacial Surgery Department - School of Dentistry -Tehran University of Medical Sciences, Tehran , Ghorbani, Y Department of Physiology - Islamic Azad University, Tehran , Kalantar Motamedi, M. H Oral and Maxillofacial Surgery -Trauma Research Center - Baqiyatallah University of Medical Sciences, Tehran , Bahrami, N Tissue Bank and Research Center - Tehran University of Medical Sciences, Tehran
Abstract :
Background: Although bone grafts are commonly used in reconstructive surgeries, they are sensitive to
local perfusion and are thus prone to severe resorption. Biphosphonates can inactivate osteoclasts and
can be used to control the undesirable bone resorption.
Objective: To assess the effect of administration of biphosphonates on bone resorption.
Methods: 20 patients with bony defects who were candidates for free autogenous grafts were randomized
into “pamidronate” and “control” groups. Bone segments were soaked in either pamidronate solution or
normal saline and were inserted into the area of the surgery. Bone densities were measured post-surgery
and in 6-month follow-up. Data were obtained via Digora software and analyzed.
Results: The mean±SD bone density in pamidronate group changed from 93.4±14.6 to 93.6±17.5 (p<0.05);
in the control group the density decreased from 89.7±13.2 to 78.9±11.4 (p<0.05). The mean difference
of bone density in anterior areas of the jaws showed higher DXA in comparison to posterior regions
(p=0.002).
Conclusion: Locally administered pamidronate affects reduction in bone resorption.
Keywords :
Bone transplantation , Pamidronate [supplementary concept] , Reconstructive surgical procedures , Oral surgical procedures
