Title of article :
Transition metal-free synthesis of quinolino[2′,3′:3,4]pyrazolo[5,1-b]quinazolin-8(6H)-ones via cascade dehydrogenation and intramolecular N-arylation
Author/Authors :
Shiri, Morteza Department of Chemistry - Faculty of Physics and Chemistry - Alzahra UniversityVanak, Tehran, Iran , Heravi, Majid M. Department of Chemistry - Faculty of Physics and Chemistry - Alzahra UniversityVanak, Tehran, Iran , Hamidi, Hoda Department of Chemistry - Faculty of Physics and Chemistry - Alzahra UniversityVanak, Tehran, Iran , Zolfigol, Mohammad A. Faculty of Chemistry - Bu-Ali Sina University, Hamedan, Iran , Zahra Tanbakouchian Faculty of Chemistry - Bu-Ali Sina University, Hamedan, Iran , Nejatinezhad-Arani, Atefeh Department of Chemistry - Faculty of Physics and Chemistry - Alzahra UniversityVanak, Tehran, Iran , Shintre, Suhas A. School of Chemistry and Physics - University of KwaZulu-Natal - Durban, South Africa , Koorbanally, Neil A. School of Chemistry and Physics - University of KwaZulu-Natal - Durban, South Africa
Abstract :
2-(2-Chloroquinolin-3-yl)-3-(arylamino)-2,3-dihydroquinazolin-4(1H)-one was converted to quinolino[2′,3′:3,4]pyrazolo[5,1-b]quinazolin-8(6H)-ones in the presence of KOtBu in DMSO at room temperature. The present method has the advantages of easy conditions, construction of highly novel five heterocycles, transition metal-free conditions, cascade dehydrogenation and intramolecular N-arylation and good to high yield of products.
Keywords :
Quinoline , Quinazolinone , Intramolecular N-arylation , Cascade reaction , Polyheterocycles , Transition metal-free
