Title of article :
Synthesis and anti-brucella activity of some new 1,3,4-oxadiazole derivatives containing a ferrocene unit
Author/Authors :
Kazemizadeh, Ali Reza Research Laboratory of MCR - Department of Chemistry - Zanjan Branch Islamic Azad University, Zanjan, Iran , Shajari, Nahid Research Laboratory of MCR - Department of Chemistry - Zanjan Branch Islamic Azad University, Zanjan, Iran , Shapouri, Reza Department of Microbiology - Zanjan Branch Islamic Azad University, Zanjan, Iran , Adibpour, Neda Department of Medicinal Chemistry - School of Pharmacy - Zanjan University of Medical Sciences, Zanjan, Iran , Teimuri-Mofrad, Reza Organic Synthesis Research Laboratory - Department of Organic and Biochemistry - Faculty of Chemistry - University of Tabriz, Tabriz, Iran
Abstract :
An isocyanide-based multicomponent reaction between cinnamic acid derivatives or 3-phenyl-2-propynoic acid, (N-isocyanimino)triphenylphosphorane, ferrocenecarbaldehyde, and dibenzylamine has been reported in excellent yields for the preparation of some new ferrocenyl-containing 1,3,4-oxadiazole derivatives. The anti-brucella activities of the products are investigated in in vitro and in vivo assays.
Keywords :
Isocyanide-based multicomponent reaction , (N-isocyanimino)triphenylphosphorane , Anti-brucella activity , Ferrocene
