Author/Authors :
Lin, Guoqiang Department Of Hematology - Huah’an Hospital Affiliated To Xuzhou Medical College, Jiangsu Province, China , Liu, Limin Department Of Hematology - Huah’an Hospital Affiliated To Xuzhou Medical College, Jiangsu Province, China , Zhao, Guangsheng Department Of Hematology - Huah’an Hospital Affiliated To Xuzhou Medical College, Jiangsu Province, China , Si, Yejun Department Of Hematology - Huah’an Hospital Affiliated To Xuzhou Medical College, Jiangsu Province, China , Zhang, Xingxia Department Of Hematology - Huah’an Hospital Affiliated To Xuzhou Medical College, Jiangsu Province, China , Sun, Yumei Department Of Hematology - Huah’an Hospital Affiliated To Xuzhou Medical College, Jiangsu Province, China , Lu, Shuhua Department Of Hematology - Huah’an Hospital Affiliated To Xuzhou Medical College, Jiangsu Province, China , Zhang, Yanming Department Of Hematology - Huah’an Hospital Affiliated To Xuzhou Medical College, Jiangsu Province, China
Abstract :
The chromosomal translocation t(14;18)(q32;q21) is commonly associated with neoplasms of follicular center cell origin and has also been reported in cases of chronic lymphocytic leukemia. However, T cell acute lymphoblastic (or lymphocytic) leukemia (T-ALL) with t(14;18)(q32;q21) has been rarely reported. Here, we report a case of myeloid antigen-positive T-ALL (My+T-ALL) with t(14;18)(q32;q21) and trisomy 10. This is the first reported case of My+T-ALL (L2) with such chromosomal abnormalities. Other published de novo ALL cases, with t(14;18)(q32;q21) and without a documented history of lymphoma, are summarized and reviewed in this report. The patient in this study was treated with remission induction therapy and intensive chemotherapy, followed by maintenance therapy. As of this writing, he has remained in remission for more than 3 years and has presented a better clinical outcome compared with other reported adult ALL patients with t(14;18)(q32;q21).
Keywords :
Chromosomal translocation , chromosomal abnormalities , lymphoma , remission induction therapy
