Title of article :
How to Change the Redox Potential of Guanine?
Author/Authors :
Pakiari, A.H Chemistry Department - College of Science - Shiraz University, Shiraz, Iran , Dehghanpisheh, E Chemistry Department - College of Science - Shiraz University, Shiraz, Iran , Haghighi, B Chemistry Department - College of Science - Shiraz University, Shiraz, Iran
Abstract :
Due to some important applications of guanine electrode in scientific and technology research such as electro-chemical DNA based
biosensors, and a problem of high redox potential of guanine (0.81 V), our research study concentrates on reducing guanine redox potential
by substituting Cu, Ag, Au, CH3, C2H5 and Cl on sites of 1, 2 and 9 of guanine. A 5.0% reduction of redox potential for 9-Ag-guanine was
the sign of favorable result. In order to have further lower potential, sliver clusters (Ag2 and Ag3) were used. The obtained percentages of
reduction of potentials were 53.6% and 36.8% for 9-Ag2 and 9-Ag3-guanine, respectively. In this research, Gaussian 09 was used and DFT
was applied with long-range corrected xc-functional (LC-BLYP).
Keywords :
Redox Potentials , Guanine , Substitutions , Biosensor
Journal title :
Astroparticle Physics
