Author/Authors :
Tekgündüz Kadir Şerafettin نويسنده Faculty of Medicine, Division of Neonatology, Atatürk
University, Erzurum, Turkey , Gürol Ayşe نويسنده Health Services Vocational School, Atatürk University,
Erzurum, Turkey , Kurt Nezahat نويسنده Faculty of Medicine, Division of Biochemistry, Atatürk
University, Erzurum, Turkey , Apay Serap Ejder نويسنده Faculty of Health Science, Department of Midwifery,
Atatürk University, Erzurum, Turkey
Abstract :
Objectives The primary purpose of this study was to investigate
the effects of phototherapy on antioxidant status of preterm and term
infants with hyperbilirubinemia. Methods Term and preterm infants were
divided to three groups; group 1: 28 to < 32 weeks, group 2: 32
to < 37 weeks, and group 3: term infants hospitalized due to
jaundice requiring phototherapy during the first to ninth day of life .
Fifty-six infants were included in this study. Levels of serum total
bilirubin, malondialdehyde, superoxide dismutase, reduced glutathione
and catalase were measured before and 24 hours after phototherapy.
Results It was found that the reduced glutathione levels in group 1
including preterm infants decreased significantly after phototherapy. It
was observed that levels of malondialdehyde increased significantly in
term infants compared to preterm infants in group 1 and group 2. It was
observed that the decreases in bilirubin and superoxide dismutase enzyme
were correlated in group 2 preterm infants and group 3 term infants.
Conclusions Phototherapy did not significantly affect the antioxidant
level in the present study. The fact that there was a significant
decrease in glutathione peroxidase levels after phototherapy only in
group 1 preterm infants suggests that more attention should be paid when
phototherapy is used in this age group.
