Author/Authors :
Ordooei Mahtab نويسنده Department of Pediatrics, Hematology, Oncology and Genetics Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, , Lotfi Mohammad Hasan نويسنده Department of Biostatistics and Epidemiology, Health Faculty, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Lotfi Mohammad Hasan , Akhondi-Meybodi Mohsen نويسنده Gastrology Department, Faculty of Medicine, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran , Pourmohammadi Behrad نويسنده Damghan School of Health, Semnan University of Medical Science, Semnan, Iran Pourmohammadi Behrad , Rahimi Pordanjani Sajjad نويسنده Instructor, Msc in Epidemiology, Department of Public
Health, Semnan University of Medical Sciences, Semnan,
Iran , Rabei Azar نويسنده Shahid Sadoughi University of Medical Sciences, Yazd,
Iran
Abstract :
Background Congenital hypothyroidism (CH) is one of the major
causes of physical and mental disabilities, which are preventable and
treatable. This study aimed to investigate physical growth and to
evaluate the effectiveness of performed therapeutic interventions on
normality of serum T4 and TSH levels in children with CH of Yazd city.
Methods This retrospective cohort study was performed on all neonates
with CH, who were born during years 2006 and 2008. The growth pattern of
height, weight and head circumference during the first five years of
children with CH and the effectiveness of performed therapeutic
interventions on normality of serum T4 and TSH levels were evaluated.
The collected data were analyzed using the 22nd version of the SPSS
software. Results The pattern of height, weight, and head circumference
of the girls with CH was comparable with the growth pattern of NCHS of
healthy individuals. The pattern of height and weight growth of boys
with CH gradually became similar to the growth pattern of NCHS of
healthy boys. However, there was a decline in their head circumference
growth trend after six months of age. Also it was revealed that
therapeutic interventions had an appropriate effect on normalization of
serum TSH, T4 levels and growth pattern in CH children under treatment.
Conclusions After treatment and care for these patients, the growth
patterns and serum T4 and TSH levels of these children reached a normal
and desirable range.
