Author/Authors :
Eftekhari Kambiz نويسنده , Najafi Sani Mehri نويسنده Children Medical Center Hospital, Tehran University School of Medical Sciences, Tehran, Iran , Monajemzadeh Maryam نويسنده Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran , Ghaderi Ebrahim نويسنده Kurdistan Research Center for Social Determinants of Health, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran , Nikkhoo Bahram نويسنده Dept. of Pathology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran Nikkhoo Bahram , Sedaghat Banafsheh نويسنده Resident, Department of Pediatrics Diseases, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran , Parizad Jaleh نويسنده Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran Parizad Jaleh , Ataee Pedram نويسنده beast hospital,Department of Pediatrics,Kurdistan University of Medical Sciences,Sanandaj,Iran , Afrasiabi Vahidreza نويسنده Department of Pediatrics, Kurdistan University of Medical
Sciences, Sanandaj, IR Iran , Rahehagh Ramesh نويسنده Department of Pathology, Kurdistan University of Medical
Sciences, Sanandaj, IR Iran , Fathollahpour Asadollah نويسنده Department of Pediatrics, Kurdistan University of Medical
Sciences, Sanandaj, IR Iran , Kariminejhad Froozan نويسنده Department of Endoscopy, Kurdistan University of Medical
Sciences, Sanandaj, IR Iran
Abstract :
Background Chronic abdominal pain in children is a common
disorder. For an accurate diagnosis of its cause, sometimes invasive
diagnostic procedures such as endoscopy should be performed. Objectives
The purpose of the study was to evaluate the fecal calprotectin in
children with upper gastrointestinal signs and symptoms and to compare
it with endoscopic findings. Methods A total of 131 children aged 1-14
years with upper gastrointestinal symptoms were enrolled during 2012 -
2013 at two centers. One hundred and twenty patients underwent endoscopy
and biopsy. Before endoscopy, the level of calprotectin was measured by
the enzyme-linked immunosorbent assay test in stool samples and the
results were compared with the endoscopic and pathology findings.
Results Of the 120 children included in this study, 71 (59.2%) were
males and 49 (40.8%) females with a mean age of 93.6 months. Of the 112
patients in whom biopsies were taken, 16 had esophagitis, 89 chronic
gastritis (79.5%) and 57 colonization with Helicobacter
pylori. Conclusions There was a statistically significant
correlation between fecal calprotectin and gastritis and severity of
H. pylori infection. Fecal calprotectin level
measurement can avoid unnecessary endoscopies and is also useful for
evaluation of therapy response.
