Author/Authors :
Zamani Farhad نويسنده , Kheyri Zahedin نويسنده Division of Gastroenterology, Hazrat-e-Rasool Hospital, Tehran University of Medical Sciences, Tehran, IR Iran , Farahani Behzad نويسنده Department of Cardiology, Firoozgar Hospital, Tehran University of Medical Science, Tehran, Iran. Farahani Behzad , Motamed Nima نويسنده Department of Community Medicine, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran , Maadi Mansooreh نويسنده Department of Social Medicine, Zanjan University of Medical Sciences, Zanjan, IR Iran , Rabiee Behnam نويسنده Gastrointestinal and Liver Disease Research Center (GILDRC), Tehran Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IR Iran , Hemasi Gholam Reza نويسنده Gastrointestinal and Liver Disease Research Center (GILDRC), Tehran Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IR Iran , Khonsari Mahmood Reza نويسنده Gastrointestinal and Liver Disease Research Center (GILDRC), Tehran Firoozgar Hospital, Iran University of Medical Sciences, Tehran, IR Iran
Abstract :
Background The association between liver enzymes and
cardiovascular disease (CVD) was previously demonstrated. This study
investigated the possible association between liver enzymes and the
10-year risk of cardiovascular events. Methods The study consisted of
3199 subjects. Two risk-assessment methods, the framingham risk score
(FRS) and American college of cardiology and American heart association
(ACC/AHA) tools, were used to predict 10-year cardiovascular risks. The
association between liver enzymes and ≥ 7.5%, ≥ 10%, and ≥ 20% 10-year
CVD risks were evaluated. Results In the multivariate analysis, alkaline
phosphatase (ALP) was significantly associated with 10-year CVD risks in
both men and women (P < 0.05). No significant association was
detected between 10-year CVD risks and gamma glutamyl transferase (GGT).
According to both risk-assessment tools, alanine aminotransferase (ALT)
showed a significant inverse association with 10-year CVD risks in men
(all P < 0.001). In contrast, this association was significant in
women only for ≥ 7.5% and ≥ 10% 10-year risks using the ACC/AHA (P =
0.018) and Framingham tools, respectively (P = 0.028). Conclusions While
ALP exhibited an independent positive association with 10-year CVD risks
in both genders, ALT showed an inverse association with10-year CVD risks
in men and with some levels of risks in women.
