Author/Authors :
Khavanin Ali نويسنده , Mirzaei Ramazan نويسنده Faculty of Health, Zahedan University of Medical Sciences, Zahedan, Iran , Mortazavi Seyed Bagher نويسنده Department of Occupational and Environmental Health, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran , Hashemi Habybabady Raheleh نويسنده Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran
Abstract :
Background Previous studies demonstrated partial attenuation of
noise induced hearing loss (NIHL) by N-acetyl-L-cysteine (NAC) or
CoQ10 (ubiquinone). Objectives The present study
investigates the protection effect of coadministration of NAC and
CoQ10 against NIHL. Methods In an experimental
study in Iran in 2015, a total of 36 male Wistar rats (275 ± 25 g) were
divided randomly based on the permuted block design into 6 experimental
groups: (I) noise controls, (II) noise and NAC, (III) noise and
CoQ10, (IV) noise and
CoQ10 and NAC, (V) noise and saline (as vehicle
of NAC) and (VI) noise and olive oil (as vehicle of
CoQ10). Antioxidants and vehicles were
intraperitoneally injected once a day for two days prior to and 1 hour
before 102 ± 0.5 dB white noise exposure 8 h/day in 10 executive days
and two days after the noise exposure daily. Distortion product
otoacoustic emissions were measured one day before and 1, 7 and 21 days
after the exposure. Results The temporary hearing changes that occurred
1-day post exposure were not significantly different in all groups (P
> 0.05). The total recovery (between 1 - 21 days after noise
exposure) varied by a frequency increase between 1.08 - 19.10 in the
noise group compared to 1.75 - 24.5 and 0.62 - 22.08 in animals treated
with NAC and the combination of NAC and CoQ10
respectively. The less permanent hearing impairment was observed in
noise exposed animals treated with either NAC or both NAC and
CoQ10. Conclusions The effect of coadministration
of NAC and CoQ10 was neither additive nor
synergic in protecting against NIHL.
