Author/Authors :
Delavari Alireza نويسنده , Mohaghegh Shalmani Hamid نويسنده , Asadi-Lari Mohsen نويسنده Oncopathology Research Centre, Tehran University of Medical Sciences, Tehran, Iran , Rezaei Negar نويسنده Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, IR Iran , Delavari Farnaz نويسنده Media and Life Promotion Group (MLPG), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Delavari Farnaz , Sheidaei Ali نويسنده , Gohari Kimiya نويسنده , Parsaeian Mahboubeh نويسنده , Farzad Far Farshad نويسنده Non-Communicable Diseases Research Center, Endocrinology
and Metabolism Population Sciences Institute, Tehran University of
Medical Sciences, Tehran, IR Iran , Khademiureh Sara نويسنده Non-Communicable Diseases Research Center, Endocrinology
and Metabolism Population Sciences Institute, Tehran University of
Medical Sciences, Tehran, IR Iran , Maghsoudlu Mahtab نويسنده Department of Research and Education and the, Blood
Transfusion Research Center, High Institute for Research and
Education in Transfusion Medicine, Tehran, IR Iran , Madadi Zahra نويسنده Non-Communicable Diseases Research Center, Endocrinology
and Metabolism Population Sciences Institute, Tehran University of
Medical Sciences, Tehran, IR Iran , Mansouri Anita نويسنده Non-Communicable Diseases Research Center, Endocrinology
and Metabolism Population Sciences Institute, Tehran University of
Medical Sciences, Tehran, IR Iran , Yoosefi Moein نويسنده Non-Communicable Diseases Research Center, Endocrinology
and Metabolism Population Sciences Institute, Tehran University of
Medical Sciences, Tehran, IR Iran
Abstract :
Background Liver cancer is a highly lethal cancer with 5 year
survival rate of about 18%. This cancer is a leading cause of death in
many countries. As there is not a comprehensive population base study on
liver cancer mortality rates by cause in national and provincial level
in Iran. We aimed to estimate the liver cancer mortality rate, its
patterns, and temporal trends during 26 years by sex, age, geographical
distribution, and cause. Methods We used the Iranian death registration
system (DRS), in addition to demographic and statistical methods, to
address the incompleteness and misclassification and uncertainty of
death registration system to estimate annual liver cancer mortality
rate. Direct age standardized approach was applied using Iran national
population 2015 as a standard population to facilitate the comparison
between the provinces. Results Liver cancer age standardized mortality
rate in Iran increased by more than four times from 1.18 (95%
uncertainty interval; 0.86 to 1.61) deaths per 100,000 person in 1990 to
5.66 (95% uncertainty interval; 4.20 to 7.63) deaths per 100,000 person
in 2015. Male to female age adjusted mortality ratio changed from 0.87
to 1.82 during the 26 years of the study. With increasing age, liver
cancer mortality rate increased in both sex and all provinces. At
provincial level, the province with highest mortality rate have 2.96
times greater rate compare to the lowest. Generally, about 71% of
mortality at national level is due to hepatitis B and C infection.
Conclusions In order to reduce liver cancer mortality rate, it is
recommended to control main risk factors including chronic hepatitis
infections. Because of the growing rate of mortality from liver cancer,
augmenting life expectancy, and increasing number of the elderly in
Iran, policy makers are more expected to adopt measures including
hepatitis B vaccination or hepatitis C treatment.
