Author/Authors :
Akbari Mohammad Esmaeil نويسنده , Reiazi Reza نويسنده Department of Medical Physics, Isfahan University of Medical Sciences, Isfahan, Iran , Norozi Amir نويسنده Health Insurance Research Center, Armed Forces Insurance Organization, Tehran, IR Iran , Etedadialiabadi Maryam نويسنده Radiology Department, Milad Hospital, Tehran, IR Iran
Abstract :
Background Recently the use of cold atmospheric plasma (CAP) for
the treatment of cancers called “Plasma Oncology” has gained promising
results. The developments have raised the hope that this technology
could be an interesting new therapeutic approach in the treatment of
cancer. Methods The process of this study includes a narrative review in
two stages. At the first stage “literature overview”, all mechanisms of
action related to cold atmospheric plasma have been reviewed. To
relevant as much as papers for this review, multiple effective
techniques have been applied in our search strategy. An extensive search
of the published literature has been conducted. Results Results of this
study include three sections as follow: the mechanism of action, in vivo
and in vitro findings, and studied focused on selectivity effect of CAP.
According to several publications, reactive oxidative species (ROS) can
be the major cause of the biological effect of plasma. Several
publications concerning in vivo and in vitro studies on different cell
lines and selectivity effect showed that there are promising results in
favor of anti-cancer effect of CAP. Conclusions The results of several
studies that are summarized within this review show that CAP is
effective against cancer which also indicate that CAP seems to be
selective for cancer cells compared to non-neoplastic cells. It has been
concluded that the feasibility of applying CAP for treating human tissue
has already gained momentum although future studies require more studies
for clarifying that if CAP is capable to discriminate between normal and
malignant cells or not.
