Author/Authors :
Mohammadi Fereshteh نويسنده , Yousofi Darani Hossein نويسنده Parasitologist, Professor, Dept of Parasitology, Shahrekord University of Medical Sciences, Shahrekord , Sharafi Seyedeh Maryam نويسنده Infectious and Tropical Disease Research Center, Isfahan University of Medical Sciences, Isfahan, , Jafari Rasool نويسنده Department of Parasitology and Mycology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran , Jafari Davod نويسنده MD, Associate Professor of Orthopedic Surgery, Shafa Yahyaian Rehabilitation Center , Sadeghpour Shadab نويسنده School of Medicine, Najafabad Branch, Islamic Azad University, Isfahan, IR Iran , Sharifi Forough نويسنده Dr. Sharifi Clinical Laboratory, Isfahan, IR Iran , Bagherpour Bahram نويسنده Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran , Soleimani Salar Pegah نويسنده Dr. Sharifi Clinical Laboratory, Isfahan, IR
Iran , Adibpour Nasim نويسنده Department of Food Science and Technology, College of
Agriculture, Isfahan University of Technology, Isfahan, IR
Iran
Abstract :
Background Toxoplasma gondii, a zoonotic
parasite, is one of the wide spread parasitic causes of asymptomatic
infection in human, yet can cause severe disease and disorders in
infants, when infected during pregnancy, and also in immunocompromised
individuals. Thus, updated information about the prevalence of the
infection in each region and time period is necessary. Objectives The
aim of the present study was to determine the prevalence of the
infection in patients referred to Dr. Sharifi clinical laboratory of
Isfahan, Iran, during January 2014 to January 2015. Methods In a
retrospective study, 1287 patients that had
anti-Toxoplasma IgM and/or IgG test from January 2013
to January 2015 were selected and included in the study. Quantitative
determination of anti-Toxoplasma IgM and IgG was
performed using antibody capture chemiluminescence immunoassay (CLIA)
kits (LIAISON® Toxo IgM and IgG, DiaSorin S.P.A, Italy) applied using
the LIAISON (DiaSorin, Germany) device. All the available variables such
as anti-Toxoplasma IgG and IgM concentrations, gender
and age were recorded and analyzed. Results Overall, 1287 cases
including 1215 (94.4%) females and 72 (5.6%) males with mean age of
28.64 years (min: 1, max: 78) were studied. The results showed that 36
(2.8%) out of 888 and 325 (25.3%) out of 1243 studied individuals were
anti-Toxoplasma IgM and IgG seropositive,
respectively. The mean age observed significantly higher in IgG positive
humans (P < 0.001), but not in IgM positive ones (P = 0.065). No
statistically significant relationship was observed for the IgM and IgG
seropositivity and concentrations among the genders. Conclusions
According to the results of the present study, prevalence of infection
with T. gondii is high in Isfahan, yet it is still
lower than most of the other studied regions in the country. Also, the
risk of the infection rises with increasing age.
