Author/Authors :
Zakerhamidi Mohammad Sadegh نويسنده Research Institute for Applied Physics and Astronomy, University of Tabriz, Tabriz-Iran Zakerhamidi Mohammad Sadegh , Mehnati Parinaz نويسنده Department of Medical Physics, School of Medicine, Tabriz
University of Medical Sciences, Tabriz, Iran , Jafari Tirtash Maede نويسنده Department of Medical Physics, School of Medicine, Tabriz
University of Medical Sciences, Tabriz, Iran , Mehnati Parisa نويسنده Research Institute for Applied Physics and Astronomy,
Tabriz University, Tabriz, Iran
Abstract :
Background Blood concentrations and oxygen saturation levels are
important biomarkers for breast cancer diagnosis. Objectives In this
study, the absorption coefficient of hemoglobin (Hb) was used to
distinguish between normal and abnormal breast tissue. Materials and
Methods A near-infrared source (637 nm) was transmitted from major and
minor vessels of a breast phantom containing 2×, 4× concentrations of
oxy- and deoxy-Hb. The absorption coefficients were determined from
spectrometer (SM) and powermeter (PM) data. Results The absorption
coefficients were 0.075 ± 0.026 cm-1 for
oxygenated Hb (normal) in major vessels and 0.141 ± 0.023
cm-1 at 4× concentration (abnormal) with SM,
whereas the breast absorption coefficients were 0.099 ± 0.017
cm-1 for oxygenated Hb (normal) in minor vessels
and 0.171 ± 0.005 cm-1 at 4× concentrations with
SM. A comparison of the data obtained using a SM and a PM was not
significant statistically. Conclusion The study of the absorption
coefficient data of different concentrations of Hb in normal and
abnormal breasts via the diffusion of near-infrared light is a valuable
method and has the potential to aid in early detection of breast
abnormalities with SM and PM in major and minor vessels.
