Author/Authors :
Nikeghbalian Saman نويسنده , Geramizadeh Bita نويسنده , Malekhosseini Seyed Ali نويسنده Transplant Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran , Salehi-Lalemarzi Hamed نويسنده Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , Baghernezhad Mohammad نويسنده Pathology Department, Transplant Research Center, Shiraz
University of Medical Sciences, Shiraz, IR Iran , Kazemi Kurosh نويسنده Department of Hepatobiliary and Liver Transplant Surgery, Shiraz University of Medical Sciences, Shiraz, IR Iran , Shamsaeefar Alireza نويسنده Department of Hepatobiliary and Liver Transplant Surgery, Shiraz University of Medical Sciences, Shiraz, IR Iran
Abstract :
Background Hepatocellular carcinoma is an unfortunate consequence
in cirrhotic patients. Most of the cases are diagnosed by imaging
modalities; however, some of them are missed and would be diagnosed only
after thorough examination of the explanted liver following
transplantation. Objectives In this study, we aimed to evaluate the
frequency of incidental HCCs that are diagnosed after transplantation
based on pathological examination of the explanted livers. Methods We
evaluated all the explanted livers during 5 years from 2012 to 2016 with
clinical and pathological diagnosis of HCC. In the meantime, all of the
clinicopathological findings were investigated such as demographic
information, AFP level, tumor size, and tumor location. Conclusions The
frequency of incidental HCC in our center was around 20%, more than 80%
of which were less than 2-cm in size (early HCC). Majority of the cases
were male patients above 40 years age, with the underlying causes of
Hepatitis B, C, and AIH as well as tyrosinemia and PFIC.
