Author/Authors :
Fereshtehnejad Seyed Mohammad نويسنده , Nilipour Yalda نويسنده , Mehrpour Masoud نويسنده Firoozgar Clinical Research Development Center (FCRDC), Neurology Department, Tehran University of Medical Sciences, Tehran, Iran , Motamed Mohammad Reza نويسنده MD, Assistant professor of neurology, Department of Neurology, Firoozgar Hospital , Haghi-Ashtiani Bahram نويسنده Department of Neurology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Haghi-Ashtiani Bahram , Almasi Mostafa نويسنده Neurology Department, Rasoul Akram Hospital, Iran
University of Medical Sciences, Tehran, Iran , Haji Akhondi Fahimeh نويسنده Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran. Haji Akhondi Fahimeh
Abstract :
Introduction: Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) can involve multiple systems and cause stroke-like episodes and status epilepticus.
Case Presentation: A 48-year-old female with history of early fatigability, migraine-type headaches, and bilateral sensory-neural hearing loss presented 3 episodes of serial seizures. On admission she was affected by Wernicke aphasia and, then, right hemiparesis. Investigations showed elevated arterial lactate and ragged red fibers on muscle biopsy.
Conclusion: Though more commonly diagnosed during childhood, some cases of adult-onset MELAS syndrome are reported. This syndrome should be considered in patients with stroke-like events in adults without cerebrovascular risk factors and difficult-to-treat seizures.
