Title of article
Neonatal Rat; A Suitable Animal Model for Experimental Cryptosporidiosis
Author/Authors
Rafiei Abdollah نويسنده , Makvandi Manoochehr نويسنده , Saki Jasem نويسنده 2. Department of Medical Parasitology, Infectious and Tropical Diseases Research Center, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran Saki Jasem , Pirestani Majid نويسنده Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran , Heidarnejadi Seyede Manizhe نويسنده Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran , Ghadiri Ataallah نويسنده Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
Pages
3
From page
1
Abstract
Background Cryptosporidiosis is a major public health problem for
neonatal livestock worldwide. Cryptosporidium parvum
infects intestinal epithelial cells via contaminated food or drinking
water and leads to cryptosporidiosis. Most of the animal model studies
on infectivity of C. parvumare conducted on the
neonatal mice. Objectives: The current study aimed at evaluating the
infectivity of C. parvum in neonatal rat as an animal
model. Methods A dose of 100,000 to 120,000 C. parvum
oocysts (Iowa strain, BTF Company, Sydney, Australia) was orally
inoculated in a group of 30 neonatal Wistar rats aged 2 days old. Eight
days postinfection, jejunum, ileum, cecum, colon, and rectum were
removed and contents were homogenized and purified using sucrose
gradient method. Results Our results indicated that 6 to 12 million
C. parvum was found per rat Conclusions Analysis of
the study results revealed that the neonatal rat could be used as an
alternative animal model to investigate C. parvum.
Journal title
Astroparticle Physics
Serial Year
2017
Record number
2409195
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