Title of article
Indium chloride (InCl3) catalysed domino protocol for the regioselective synthesis of highly functionalized pyranopyrazoles under mild conditions
Author/Authors
سورواس داتاتري ان نويسنده Organic Chemistry Research Laboratory, Department of Chemistry, Rajaram College Kolhapur, Maharashtra, India Survase Dattatray N. , چاوان همانت وي نويسنده Department of Chemistry, A.S.P. College Devrukh, Dist-Ratnagiri, Maharashtra, India-415804 Chavan Hemant V. , دنگر ساكارام بي نويسنده Medicinal chemistry Research Laboratory, School of Chemical Science, Solapur University Solapur, Maharashtra, India-413255 Dongare Sakharam B. , گاناپور شريرام دي نويسنده Medicinal chemistry Research Laboratory, School of Chemical Science, Solapur University Solapur, Maharashtra, India-413255 Ganapure Shreeram D. , هلاويا واسانت بي نويسنده Organic Chemistry Research Laboratory, Department of Chemistry, Rajaram College Kolhapur, Maharashtra, India Helavia Vasant B.
Pages
10
From page
105
Abstract
Regioselective synthesis of highly functionalized pyranopyrazoles was achieved in excellent yield from phenyl pyrazolone, substituted aromatic aldehyde with nitroketene-N,S-acetal in the presence of indium trichloride as a versatile catalyst under reflux condition in ethanol-water mixture. All reactions proceeded within a short period of time with excellent purity. All of the synthesized compounds were identified by IR, 1H NMR, 13C NMR and mass spectroscopy. Quantitative yields, inexpensive and environmentally friendly solvent system and simple work-up procedure are the attractive features of the present method. It is thus enviro-economic method without producing hazardous wastes. The formed pyranopyrazoles might find to possess important biological and pharmaceutical applications.
Journal title
Astroparticle Physics
Record number
2409492
Link To Document