Comparison of Beta-2 Microglobulin Level and Some Variables Between Thalassemia Major Patients Who Treated by Desferal and Control Group

[Background]Iron over load will be appearing in kidney following blood transfusion. Desferal as an iron chelator can be ended renal complication.[Objectives]The aim of this study is evaluation the level of β2 microglobulin in β- Thalassemia major patients for follow up proximal tubular damage.[Methods]In this descriptive and analytic study 40 thalassemic patients who were treated by Desferal and 40 healthy subjects enrolled in this study randomly. For evaluation the proximal tubular damage in these groups, we measured the β-2 microglobin. Another variable such as: Ca, Mg, P and Urea of blood and K, Cr, protein and volume of urine 24 hours were measured. We compared these variables between two groups. And descriptive and analytic analyses were used.[Results]The level of β2 microglobulin had significant difference in both groups, also the level of Ca, K and β-2 Globin in serum and Cr, protein and urine volume in 24 houres had significant difference.[Conclusions]The higher level of β2 microglobulin in Thalassemia major patient who were treated by Desferal, show the proximal tubular damage.