Author/Authors :
Liu Ping نويسنده , Pan Jie نويسنده , Zhou Jiajia نويسنده Department of Neurology, College of Medical, the First
Affiliated Hospital, Zhejiang University School of Medicine,
Hangzhou, Zhejiang, China , Gu Yali نويسنده Department of Neurology, College of Medical, the First
Affiliated Hospital, Zhejiang University School of Medicine,
Hangzhou, Zhejiang, China , Luo Benyan نويسنده Department of Neurology, College of Medical, the First
Affiliated Hospital, Zhejiang University School of Medicine,
Hangzhou, Zhejiang, China
Abstract :
Background The leptomeningeal collateral (LMC) is dynamic in
ischemic stroke especially in internal carotid artery (ICA) and middle
cerebral artery (MCA) disorders. Transcranial doppler (TCD) is the only
noninvasive and portable technique for the LMC; however, there is no
standard for TCD in LMC assessment. Objectives To establish a reference
for TCD to assess the LMC in severe occlusive ICA and MCA disorders.
Patients and Methods Forty-four patients were divided into two groups
according to the LMC flow in digital subtraction angiography (DSA). The
velocities of the bilateral MCA, anterior cerebral artery (ACA), and
posterior cerebral artery (PCA) were analyzed. Results In the ACA-LMC
group, the ratio of the stenosis-side ACA and MCA were significantly
increased for the systolic velocity (P = 0.003). The sensitivities and
specificities were 68.4% and 80.0%, respectively, when the ratio was
2.27 (P = 0.006). In the PCA-LMC group, the ratio of the stenosal side
PCA and the opposite side PCA were significantly increased for the
diastolic velocity (P = 0.031). The sensitivities and specificities were
77.8% and 75.0%, respectively, when the ratio was 1.38 (P = 0.026).
Conclusion TCD is a reliable tool for LMC assessment in patients with
severe occlusive ICA and MCA disorders.
