Author/Authors :
Safa Omid نويسنده , Tanideh Nader نويسنده , Omidi Mahmoud نويسنده Department of Toxicology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. , Koohi Hosseinabadi Omid نويسنده Stem cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. , Zarshenas Mohammad Mehdi نويسنده Essence of Parsiyan Wisdom Institute, Traditional Medicine and Medicinal Plant Incubator, Shiraz University of Medical Sciences, Shiraz, Iran. , Kheradmand Saeedeh نويسنده Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. , Mokhtari Maral نويسنده Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran. , Seddigh Anahita نويسنده Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. , Jamshidzadeh Akram نويسنده Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. , Shirazi Yeganeh Babak نويسنده Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. , Daneshi Sajad نويسنده Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract :
Introduction: burn wounds are common happenings which cause many people have irreversible defects and to be dead around the world every year. In this study, we evaluated the effects of Melilotus officinalis (M. officinalis) and Alpha ointment in the healing of burn wounds and compare their findings with silver sulfadiazine (SSD). Seventy-five male Sprague-Dawley rats were randomly divided into five groups, and similar burn ulcers were produced on the back of rats. The first group of rats received no treatment, the base gel was used topically to group II, in groups III-V, Alpha, SSD and M. officinalis preparations were applied, respectively. Wound healing, contraction and histopathological examination were evaluated at the end of 7, 14, and 21 days. Alpha ointment was equally effective as M. officinalis gel, while its efficacy was better compared to SSD for all parameters of wound healing on days 7, 14 and 21. Alpha and M. officinalis preparations as less expensive medications which significantly improve the quality of wound healing and scar formation and also are more appropriate treatment choices than SSD. Alpha and M. officinalis are recommended as the alternative to SSD, especially in patients with low economic backgrounds or in those who show adverse reactions to SSD.
