Title of article
De-Novo Autoimmune Hepatitis with Consecutive Acute Liver Failure Induced by Hepatitis E Infection: A Case Report
Author/Authors
A. Baba Hideo نويسنده Department of Pathology, University Hospital, University Duisburg Essen, Germany , Canbay Ali نويسنده Department of Gastroenterology and Hepatology, University Hospital, University Duisburg Essen, Germany , Gerken Guido نويسنده Department of Gastroenterology and Hepatology, University Hospital, University Duisburg Essen, Germany , Kahraman Alisan نويسنده Department of Gastroenterology and Hepatology, University Hospital, University Duisburg Essen, Germany , Thodou Victoria نويسنده Department of Gastroenterology and Hepatology, University Clinic Essen, Germany , Buechter Matthias نويسنده Department of Gastroenterology and Hepatology, University Clinic Essen, Germany , Kalsch Julia نويسنده Department of Gastroenterology and Hepatology, University Clinic Essen, Germany
Pages
4
From page
1
Abstract
A 49-year-old male patient was referred to our institution for
acute liver failure (ALV). Apart from cholestasis, coagulopathy, and
hepatic encephalopathy (HE) I°, laboratory studies revealed a
significant increase in liver enzymes with an alanine aminotransferase
(ALT) level of 4’108 U/L and an aspartate aminotransferase (AST) level
of 3’878 U/l (normal < 50 U/L), a constellation essentially
compatible with autoimmune hepatitis (AIH). Work-up of serological
markers for hepatitis E (HEV-IgM and PCR) was at the same time positive.
Furthermore, the patient was strongly positive for antinuclear
autoantibodies (ANA) with a titer of 1:1’280 (normal upper limit 1:80),
and also presented hypergammaglobulinemia (immunoglobulin IgG-level of
21.3 g/L; normal 7, 0 - 16, 0 g/L). Liver histology demonstrated massive
hepatitis and necrosis with the presence of plasma cells. Due to the
diagnosis of de-novo autoimmune hepatitis, therapy with steroids was
performed despite the evidence of acute HEV-infection. It was of great
importance that the patient recovered completely while neither antiviral
therapy with ribavirin nor liver transplantation (LT) was necessary in
the further course.
Journal title
Astroparticle Physics
Serial Year
2017
Record number
2409813
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