Author/Authors :
Park Jae-Woo نويسنده , Adibi Peyman نويسنده , Kamalinejad Mohammad نويسنده , Naseri Mohsen نويسنده , Feizi Awat نويسنده Faculty of Epidemiology and Biostatistics, Isfahan University of Medical Sciences, Isfahan , Hasheminejad Seyed Abbas نويسنده Department of Traditional Iranian Medicine Hasheminejad Seyed Abbas , Emadi Tarkami Seyyedeh Fatemeh نويسنده Dept. of Internal Medicine, Sary University of medical sciences, Sary , Babaeian Mahmoud نويسنده Department of Iranian Traditional Medicine, Faculty of
Medicine, Shahed University, Tehran, IR Iran , Ghaffari Farzaneh نويسنده Department of History of Medicine, School of Traditional
Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR
Iran , Rafiei Rahmatollah نويسنده Internal Medicine Department, Islamic Azad University,
Najafabad Branch, Isfahan, IR Iran , Mazaheri Mohammad نويسنده Assistant Professor, Traditional Medicine, Medical School,
Isfahan University of Medical Sciences, Isfahan, IR
Iran
Abstract :
Background Functional dyspepsia (FD) is a common gastrointestinal
disease that has various treatments, including medicinal plants.
Objectives The current study aimed to investigate the effect of
Mentha longifolia on relieving the symptoms and
improving the quality of life (QOL) in patients with functional
dyspepsia from the subgroup of postprandial distress syndrome (PDS).
Patients and Methods This randomized, double-blind, placebo-controlled
trial was conducted in a gastroenterology clinic affiliated with Isfahan
University of Medical Sciences. One hundred patients diagnosed with PDS
according to the ROME III criteria were assigned to two groups: the
M. longifolia capsules (three times daily for four
weeks) group and the placebo group. Tools for gathering data were the FD
severity scale and QOL (Persian version of the SF-36 questionnaire).
Assessments of FD symptoms were obtained at baseline and also at the end
of weeks 2, 4, and 12. QOL was evaluated at baseline and at the end of
week 12. Results At the end of treatment period, the M.
longifolia group reported a more significant improvement in
the mean severity scales of FD symptoms than the placebo group (P
< 0.001). A significant difference was also observed between FD
symptoms and severity scores in the two groups eight weeks after the
medication was stopped. At the end of the fourth week, the greatest
degrees of relief regarding epigastric bloating (70.5% vs. 21.4%, P
< 0.001), epigastric fullness (68.2% vs. 31%, P < 0.001),
loss of appetite (34.1% vs. 9.5%, P = 0.014) and early satiety (36.3%
vs. 21.4%, P = 0.02) were observed in the control group. With
M. longifolia, significant improvement in the scores
of QOL was observed for the dimensions of general health, role-physical,
social functioning, bodily pain, vitality, and mental health.
Conclusions This study showed the efficacy of M.
longifolia in relieving PDS symptoms and improving the QOL of
patients with PDS.
