Author/Authors :
Shariat Moharari Reza نويسنده Associate Professor of Anesthesiology , Etezadi Farhad نويسنده Assistant Professor of Anesthesiology , Khajavi Mohammad Reza نويسنده Associate Professor of Anesthesiology , Imani Farsad نويسنده Anesthesiology and Critical Care, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Imani Farsad , Pourfakhr Pejman نويسنده Department of Anesthesiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Pourfakhr Pejman , Ahmadi Tabatabaei Azadeh نويسنده Resident of Anesthesiology, Department of Anesthesiology
and Critical Care, Tehran University of Medical Sciences, Tehran, IR
Iran
Abstract :
Background Aminophylline expedites the recovery from total
intravenous and inhalation anesthesia. Objectives The aim of this study
was to evaluate low and high doses of aminophylline on extubation time,
time to discharge from recovery, and the bispectral index score (BIS) in
patients who received isoflurane anesthesia. Patients and Methods After
ethical approval and informed consent were obtained, this prospective,
randomized, blinded clinical study was conducted in Sina hospital in
Iran. Seventy-five patients who were scheduled for elective laparatomy
surgery under isoflurane anesthesia were randomly allocated to receive
either saline or 1 or 5 mg/kg of aminophylline (n = 25 for each) at the
end of their anesthesia. The time to tracheal extubation and BIS after
the administration of the study drug and the total time required until
discharge from the post anesthesia care unit (PACU) were recorded.
Results Seventy-five patients completed the study. Compared to saline,
patients who received 1 and 5 mg/kg of aminophylline demonstrated
decreased extubation times (mean ± SD) (12.26 ± 7.33 vs. 11.15 ± 8.62
and 10.4 ± 4.78 min, respectively, P = 0.001) with higher BIS values (P
= 0.001). However, the recovery and discharge times from the PACU were
no different between the aminophylline and saline groups. Conclusions
The administration of high doses of aminophylline after laparatomy
procedures with isoflurane anesthesia expedited the extubation time with
no effects on discharge from the PACU.
