Author/Authors :
Keyhani Manoutchehr نويسنده Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran , Jalaeikhoo Hasan نويسنده AJA Cancer Epidemiology Research Center, AJA University of
Medical Sciences, Tehran, Iran , Sharifzadeh Morteza نويسنده AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran , Rajaeinejad Mohsen نويسنده AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran , Zokaasadi Mohammad نويسنده AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, Iran
Abstract :
Background: Neutrophil to lymphocyte ratio was initially used as a low cost
prognostic marker in a group of solid tumors and subsequently hypothesized to have
a role in multiple myeloma. This retrospective analysis aimed to report the prognostic
importance of the neutrophil to lymphocyte ratio in multiple myeloma.
Methods: Between November 2003 and February 2016, we included 175 patients
from two centers in this study. CBC differentials were primarily checked by a Sysmex
analyzer in both centers. In one center, differentials were rechecked by light microscopy.
Analysis of survival was performed using a Kaplan-Meier estimate and we assessed
the effects of prognostic factors by Cox proportional hazards model.
Results: Patients had a mean age of 63.22±10.89 years. Although mean lymphocyte
percent did not differ between the two centers, mean neutrophil percent and mean
neutrophil to lymphocyte ratio were higher at the center that manually checked the CBC
differentials. After adjustments for age and gender, we noted that the hazard ratio for
elevated neutrophil to lymphocyte ratio when stratified for the centers was 1.07 (95%
CI: 1.01–1.15, P=0.034).
Conclusion: A precisely checked neutrophil to lymphocyte ratio could act as a
potentially inexpensive, accessible prognostic factor for multiple myeloma patients.