Author/Authors :
Zhang Ying نويسنده , Yuan Shao-Yong نويسنده The Chinese people’s liberatin army 401 hospital,Qing Dao,P.R. China , Zou Li-Ping نويسنده Department of Pediatrics, Chinese PLA General Hospital, Beijing, P.R. China , Ding Ying-Xue نويسنده Department of Pediatrics, Beijing Friendship Hospital,Capital Medical University, Beijing, P.R. China , He Bing نويسنده Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Abstract :
[Background]Infantile spasm (IS) is a catastrophic epileptic syndrome of childhood and is usually insensitive to conventional antiepileptic drugs. Studies revealed that prenatal stress (PS) exposure and Melanocortin-2 Receptor (MC2R) may be involved in the pathogenesis of IS. However, the exact mechanism still remains unknown.[Methods]In this study, PS was initially given to Wistar rats and ACTH injection was performed in offsprings. Seizure was then induced and evaluated, followed by MC2R immunohistochemistry and expression detection.[Results]Significant differences in seizure number, MC2R and CRH expressions were observed among different subgroups.[Conclusions]Our study suggested that PS exposure may be an important factor in the pathogenesis of IS. ACTH together with low expression of MC2R, may inhibit IS seizures.
