Author/Authors :
Salehi Bahareh نويسنده Faculty of Medical Sciences , North Branch , Fatemi Mohammad Javad نويسنده Department of Plastic and Reconstructive Surgery, Burn Research Center, Tehran University of Medical Sciences, Tehran, Iran Fatemi Mohammad Javad , Taghavi Shahrzad نويسنده General Physician, Burn Research Center, Tehran University of Medical Sciences, Tehran, Iran Taghavi Shahrzad , Nikoumaram Babak نويسنده Department of Plastic and Reconstructive Surgery, Tehran Azad Medical University, Tehran, Iran , Saberi Isfeedvajani Mohsen نويسنده Medicine, Quran and Hadith Research Center and Department of Community Medicine, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran , Nematzadeh Zeinab نويسنده Department of General Physician, Burn Research Center, Iran University of Medical Sciences, Tehran, Iran , Araghi Shirin نويسنده Department of Nursing, Burn Research Center, Iran University of Medical Sciences, Tehran, Iran
Abstract :
[Objectives]The objective of the present study was to compare the use of Hirudoid immediately after surgery with its use 6 hours post-operatively when probable thrombosis was formed but tissue damage was still reversible.[Methods]After preparing 3 × 11 cm dorsal flap in all rats, one group of 8 rats received Hirudoid topically immediately after surgery during 9 post-operative days. Another group received it 6 h after surgery during 9 post-operative days. The control group received Vaseline immediately after surgery on a daily basis during 9 post-operative days.[Results]The mean area of flap survival in the control group was 8.75 ± 3.32 cm2 (mean ± SD) and it was 12.38±1.93 cm² and 14.36 ± 3.51 cm2 in Hirudoid immediately after surgery and 6 hours after surgery groups, respectively.[Conclusions]It was found that Hirudoid can be effective in improving flap viability; although its effect was not statistically significant when used immediately after surgery (P > 0.05), it significantly increased flap survival when used 6 h after surgery (P = 0.003).
