Author/Authors :
Parsian Hadi نويسنده Department of Biochemistry & Biophysics, Babol University of Medical Sciences, Babol, Iran. , Kazerouni Faranak نويسنده Department of Laboratory Medicine, Faculty of Paramedical Sciences, Shahid Beheshti University, MC, Tehran , Zabihi Ebrahim نويسنده Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran Zabihi Ebrahim , Rahimipour Ali نويسنده Proteomics Research Center, Faculty of Paramedical Sciences , Mohammadi Abandansari Rouzbeh نويسنده Department of Medical Laboratory Technology, Faculty of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , Porbagher Roghaye نويسنده Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Abstract :
[Background]Doxorubicin (DOX) therapy is the first step in the treatment of several malignancies such as prostate cancer. Drug resistance is the main drawback of this agent. Royal jelly (RJ), used to prevent or cure many diseases, is a substance produced by honey bee.[Objectives]The aim of this study was to determine the cytotoxic effect of DOX and RJ on prostate cancer cells, PC3.[Methods]Cell viability of the three experimental groups (RJ-treated cells, DOX-treated cells and RJ followed by DOX-treated cells) was assessed by 3-(4,5-dimethylthiazoyl-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.[Results]RJ-treatment increased the cytotoxic effect of DOX on PC3 cells. Namely, the effect of low dose of DOX in combination with RJ was approximately similar to that of high dose of DOX without RJ combination.[Conclusions]Any natural substances that amplify the cytotoxic effect of DOX and have the potential to save normal cells can be potentially used as a therapeutic agent which can decrease the side effects of DOX-treatment. RJ has shown to play this role in the present study.
