Author/Authors :
Lv Tao نويسنده State Key Laboratory for Diagnosis and Treatment of
Infectious Diseases, The First Affiliated Hospital, School of
Medicine, Zhejiang University , Gu Silan نويسنده State Key Laboratory for Diagnosis and Treatment of
Infectious Diseases, The First Affiliated Hospital, School of
Medicine, Zhejiang University , Shen Ping نويسنده State Key Laboratory for Diagnosis and Treatment of
Infectious Diseases, The First Affiliated Hospital, School of
Medicine, Zhejiang University , Fang Yunhui نويسنده State Key Laboratory for Diagnosis and Treatment of
Infectious Diseases, The First Affiliated Hospital, School of
Medicine, Zhejiang University , Chen Yunbo نويسنده State Key Laboratory for Diagnosis and Treatment of
Infectious Diseases, The First Affiliated Hospital, School of
Medicine, Zhejiang University , Gui Qiaodi نويسنده Department of Clinical Laboratory, Shaanxi Provincial People’s Hospital, Xian, China , Xu Qiaomai نويسنده State Key Lab for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China , Quan Jiazheng نويسنده State Key Lab for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China , Ye Guangyong نويسنده Department of Clinical Laboratory, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, China , Li Lanjuan نويسنده State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Abstract :
[Background]Liver disease represents a risk factor for Clostridium difficile infection (CDI). However, CDI predisposition and its incidence in patients with chronic hepatitis B (CHB) have not been well-characterized.[Objectives]This study aimed at determining the incidence and risk factors of CDI in CHB patients without cirrhosis.[Methods]A retrospective case-control study was conducted on hospitalized patients in a Chinese tertiary hospital between June 2010 and June 2016.[Results]A total of 105 CHB patients without cirrhosis were included in the present study. Among these patients, 35 (33%) patients developed hospital-acquired CDI. A total of 35 toxigenic C. difficile strains were assigned to 15 different STs by multi-locus sequence typing (MLST). Multivariate analysis indicated that prolonged hospital stay (OR: 1.045; 95% CI: 1.006 to 1.086) and higher Charlson scores on admission (OR: 3.063; 95% CI: 1.602 to 5.857) were independent factors for the development of CDI among CHB patients without cirrhosis.[Conclusions]A high incidence of CDI was detected in this cohort of CHB patients. Both the prolonged hospital stay and higher Charlson scores made CHB patients more susceptible to hospital-acquired CDI. Greater emphasis on infection control measures and antimicrobial stewardship in patients with CHB during hospital admission is needed.
