Title of article :
Association of Rubella, Cytomegalovirus, and Toxoplasma Infections with Recurrent Miscarriages in Bonab-Iran: A Case-Control Study
Author/Authors :
Mahdavi Saman نويسنده , Hajazimian Saba نويسنده Department of Molecular Biology, Tabriz Branch, Islamic Azad University, Tabriz, Iran , Nasirpour Hesam نويسنده Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University, Tabriz Branch, Tabriz, Iran , Azari Key Yashar نويسنده Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran , Kazemipur Nasrin نويسنده Department of Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran , Majidpour Mehdi نويسنده Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University, Tabriz Branch, Tabriz, Iran , Issazadeh Alireza نويسنده Department of Genetics, Tabriz Branch, Islamic Azad University, Tabriz, Iran , Taefehshokr Sina نويسنده Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Abstract :
[Background]Recurrent miscarriage is defined as a condition with two or more consecutive abortions before the 20 weeks of gestation. Recurrent miscarriage is a multi-factorial disease, which occurs in approximately 1% - 2% of women at the reproductive age. Congenital infection is one of the most important factors in the recurrent miscarriages.[Objectives]The aim of this study was to investigate the effects of rubella, cytomegalovirus, and toxoplasma infections on recurrent miscarriage in Bonab county.[Methods]This is a case-control study. Blood samples from a total of 100 women with recurrent miscarriage and 100 healthy women aged 20 to 35 years were taken and serum were separated. Antibodies against Rubella, Cytomegalovirus, and Toxoplasma were read by direct enzyme-linked immunosorbent assay (ELISA). Finally, data were statistically analyzed.[Results]A total of 31 patients and 14 controls were positive for IgG antibodies against Toxoplasma. In addition, 27 persons in the patient group and 11 in the control group were positive for the presence of IgG antibodies against Cytomegalovirus. A total of 29 patients and 11 controls were positive for IgG antibodies against Rubella.[Conclusion]In this study, there was a significant difference in the prevalence of anti-Rubella, Cytomegalovirus, and Toxoplasma antibodies between women with recurrent miscarriage and healthy women.
