Author/Authors :
Hashemi Ali نويسنده Shahid Beheshti University of Medical Sciences , Goudarzi Hossein نويسنده Shahid Beheshti University of Medical Sciences , Sabzehali Fattaneh نويسنده Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran , Erfanimanesh Soroor نويسنده Department of Microbiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , Dadashi Masoud نويسنده Depratment of Microbiology,School of Medicine,Shahid Beheshti University of Medical Sciences,Tehran,Iran , Roshani Mahdaneh نويسنده Depatrment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
[Background]Bloodstream infection is one of the most life-threatening complications recognized as the frequent cause of treatment failure in children with acute lymphoblastic leukemia.[Objectives]In this study, we describe the isolation of an extended-spectrum β-lactamase (ESBL)-producing Escherichia coli.[Methods]Antimicrobial susceptibility tests were determined on the isolate by the Kirby-Bauer disk diffusion method. In addition, ESBL production of the isolate was examined using the Combination Disk Diffusion Test (CDDT). PCR was used to screen the presence of CTX-M-1, CTX-M-2, CTX-M-8, CTX-M-9, CTX-M-25, ISEcp1, IS26, and IS903 genes in this isolate.[Results]We found an ESBL-producing E. coli in a 1-month-old infant with a blood cancer that carried CTX-M-1 group enzymes.[Conclusions]Our finding emphasized the need for more precise screening methods to identify the causative infectious agents at early stages of infection to choose the appropriate treatment in these severely immunocompromised patients.
