New Insight into the Relation between Adiponectin a nd Diabetes

Diabetes mellitus is a group of metabolic diseases. Insulin resistance is defined as a state that needs more in sulin to get the biological effects achieved by a lower amount of in sulin in the normal state. Several molecules which are secreted through adipocytes have been involved in insulin resistance and type 2 diabetes mellitus. Adiponectin as a 244 amino acid protein is exclusively expressed in differentiated adipocytes. Recent studies indicated impaired multimerization of adiponectin i s associated with type 2 diabetes development. Moreover, the rel ationship between adiponectin, insulin and insulin resistance is not known and many mechanisms have been proposed. Inverse rel ationship between adiponectin and insulin resistance may be m ediated through insulin and other hormones like catecholami nes or androgens. Moreover, intensive insulin treatment in creased serum C-peptide and adiponectin level resulted to i mproving sensitivity of insulin and decreased CRP level. Acc ording to these studies, it seems that adiponectin may be an important modulator of insulin action for enhancing of sensit ivity of insulin.