Author/Authors :
Aghahosseini Marzieh نويسنده , Aleyasin Ashraf نويسنده MD, Professor of Gynecology and Obstetrics, Shariati Hospital, Tehran University of Medical Sciences , Mahdavi Atossa نويسنده Department of Obstetrics and Gynecology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran , Sarfjoo Fatemeh Sadat نويسنده Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran , Yaraghi Mansooreh نويسنده Department of Obstetrics - Gynecology and Pelvic Floor Disorders - Shariati Hospital - Tehran University of Medical Sciences - Tehran , Saeedabadi Hojattollah نويسنده Department of Embryology - Shariati Hospital - Tehran University of Medical Sciences - Tehran
Abstract :
Background: The effect of elevated progesterone level on human chorionic gonadotropin (HCG) day in in vitro fertilization cycles is controversial. Some suppose that rise in progesterone level seems to have a negative impact on implantation and pregnancy by desynchronizing the endometrium, while others disagree.
Objective: To evaluate the superiority of the frozen cycle over fresh cycle on live birth in patients with elevated progesterone level on HCG day.
Materials and Methods: In this double-blind, randomized clinical trial, 72 women undergoing assisted reproductive technology with elevated progesterone level (≥1.8 ng/dl) on HCG day were included. The participants were grouped by fresh versus frozen embryo transfer, randomly. Finally, the clinical pregnancy and live birth rate were compared.
Results: The implantation rate was 21.51%. The clinical pregnancy rate was 47.22% in fresh embryo transfer group (17/36) and 41.66% in frozen group (15/36) (p=0. 40). The live birth rate was not significantly difference between two groups (p=0.56).
Conclusion: None of the fresh and frozen cycles are superior to the other and we recommend individualizing the decision for each patient. The frozen cycle may impose more emotional stress on patients
