Author/Authors :
Vaezi Marjan نويسنده Functional Neurosurgery Research Center, Shohada Tajrish
Neurosurgical Center of Excellence, Shohada Tajrish Hospital, Shahid
Beheshti University of Medical Sciences, Tehran, IR
Iran , Yourdkhani Fatemeh نويسنده Neurologist, Shahid Rajaee Hospital, Karaj, Iran , Seddighi Amir Saied نويسنده Functional Neurosurgery Research Center, Shohada Tajrish Hospital,Shahid Beheshti University of Medical Sciences,Tehran,Iran , Seddighi Afsoun نويسنده Functional Neurosurgery Research Center, Shohada Tajrish Hospital,Shahid Beheshti University of Medical Sciences,Tehran,Iran , Alereza Amiri Reza نويسنده Functional Neurosurgery Research Center, Shohada Tajrish Hospital,Shahid Beheshti University of Medical Sciences,Tehran,Iran , Naimian Shoeib نويسنده Department of Neurology,Qazvin University of Medical Sciences,Qazvin,Iran , Zoherhvand Amirhossein نويسنده Shohada Tajrish Neurosurgical Center of Excellence -Shohada Tajrish Hospital - Shahid Beheshti Uninversity of Medical Sciences, Tehran, Iran , Orai Yazdani Saeed نويسنده Shohada Tajrish Neurosurgical Center of Excellence -Shohada Tajrish Hospital - Shahid Beheshti Uninversity of Medical Sciences, Tehran, Iran , Ommi Davood نويسنده Shohada Tajrish Neurosurgical Center of Excellence -Shohada Tajrish Hospital - Shahid Beheshti Uninversity of Medical Sciences, Tehran, Iran , Sheykhi Alireza نويسنده Shohada Tajrish Neurosurgical Center of Excellence -Shohada Tajrish Hospital - Shahid Beheshti Uninversity of Medical Sciences, Tehran, Iran
Abstract :
Brain tumors in elderly are increasing as the number of people, who comprise the older population, does.About half of the patients with brain tumors appear to be over 60 years of age.In this review article, Glioblastoma multiform, as the most common malignant tumor of the central nervous system in elderly is discussed in details of definition, prognosis, diagnosis, treatment and differential diagnosis. Other tumors such as meningioma, pituitary adenoma, CNS lymphoma and metastasis are also included to be reviewed. Treatment plans, either conservative or aggressive, classic or novel, approved or under investigation, are presented. Furthermore different attitudes of treatment in the past and recently are also argued. Conventional therapy, Surgery, Radiotherapy, chemotherapy radioimmunotherapy, hormonal therapy and some other novel methods of treatments are discussed in details for the glioma.Determining factors which may be associated to the patientʹs response to each treatment planare also discussed. Finally, some age related issues are provided to be paid attention to consider an old patient with brain tumor, and planning an optimal treatment in order to make the best management decisions.Until recently, peoplewith brain tumors in elderly, were used to be treated in conservative plans and often were excluded of the clinical trials but now the number of patients who desire and receive more aggressive therapy for brain tumors is increasing
