Author/Authors :
Hantoushzadeh Sedigheh نويسنده , Zali Hakimeh نويسنده , Mousavi Masoumea نويسنده Proteomics Research Center, Faculty of Paramedical Sciences , Nejadi Naser نويسنده Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. , Mohammadpoor Masti Setareh نويسنده Proteomics Research Center - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences , Hosseini Zohreh Sadat نويسنده Proteomics Research Center - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences , Gorgani-Firuzjaee Sattar نويسنده Department of Biochemistry - Faculty of Medicine - AJA University of Medical Sciences , Rezaei Tavirani Mostafa نويسنده Proteomics Research Center - Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences , Golmohammadi Taghi نويسنده Department of Clinical Biochemistry - Faculty of Medicine - Tehran University of Medical Sciences
Abstract :
The aim of this investigation was conducted to proteomic analysis of plasma obtained from pregnant women who destined to develop late-onset preeclampsia without intrauterine growth restriction (IUGR) during 16th week of gestation. Plasma was obtained from primiparous women during 16th week of gestation. 2-DE proteomic analysis was done for plasma from 11 healthy pregnant women and 11 women who developed preeclampsia later. Using bioinformatic analysis with Progenesis SameSpots ver4.0 software and ANOVA test, expression of 2 spots were statistically different between two groups. In preeclamptic state, expression of both were decreased, one of these spots was vitamin D binding protein (p-value: 0.047), the other one will be discussed in another paper. According to results, we concluded that during 16th week of gestation, occurance of late-onset preeclampsia without IUGR is predictable. During this week, pathology of disease is present and may be the process of placental degeneration and impaired placentation are include in disease pathology.
