Title of article :
Causes of Persistently Elevated Alanine Aminotransferase Levels in Patients who Presented to Two Referral Hospitals in Mashhad, Iran during 2011
Author/Authors :
Khosravi Khorashad Ahmad نويسنده Education Development Office, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IRAN , Ahadi Mitra نويسنده Dept. of Radiation oncology, Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , Mokhtari Amirmajdi Elham نويسنده , Vossoughinia Hasan نويسنده Ghaem Hospital - Mashhad University of Medical Sciences , Saadatnia Hasan نويسنده Ghaem Hospital - Mashhad University of Medical Sciences , Esmaelzadeh Abbas نويسنده Emam Reza Hospital - Mashhad University of Medical Sciences , Farzanehfar Mohammad Reza نويسنده Ghaem Hospital - Mashhad University of Medical Sciences , Hosseini Mossareza نويسنده Ghaem Hospital - Mashhad University of Medical Sciences , Afzalaghaii Monavvar نويسنده Department of Community and Public Health - Mashhad University of Medical Sciences , Barari Linda نويسنده Mashhad University of Medical Sciences , Saadatnia Farzad نويسنده Tehran University of Medical Sciences
Abstract :
BACKGROUND Worldwide, chronic liver disease is a major cause of morbidity and mortality. Causes of elevated serum alanine aminotransferase (ALT) levels vary depending on the population under study. The aim of this study is to evaluate the frequency and causes of persistently elevated ALT levels in patients of the Gastroenterology (GI) Clinics in Ghaem and Emam Reza Hospitals in Mashhad, Iran. METHODS A total of 100 consecutive patients with persistently elevated ALT levels that referred to the GI Clinics at Ghaem and Emam Reza Hospitals in 2011 were studied. Elevated levels were defied as ALT ?40 U/L at least twice within six months. A comprehensive history that included previous surgeries, transfusion, alcohol consumption and medications was obtained. Patients underwent physical examinations, laboratory analyses and ultrasonography studies. When necessary, liver biopsies were performed. RESULTS Patients’ mean age was 44.4 ± 11.83 years. Females comprised 62% of cases. Patients presented with the following conditions: non-alcoholic fatty liver disease (NAFLD, 55%), hepatitis B (17%), autoimmune hepatitis (13%), hepatitis C (4%), autoimmune hepatitis and hepatitis C (2%), overlapping autoimmune disease (2%), Wilson disease (1%), celiac disease (1%), alcoholic hepatitis (1%), primary biliary cirrhosis (PBC, 1%), primary sclerosing cholangitis (PSC, 1%), and cryptogenic (2%). CONCLUSION NAFLD was the most common cause of persistently elevated serum ALT levels in this study.
Journal title :
Astroparticle Physics
