Analgesic, anti-inflammatory and antiarthritic activity of newly synthesized bicyclothieno 1, 2, 3 - triazines

The novel bicyclo thieno 1, 2, 3-triazines (BTT) namely BTT-1, BTT-2, BTT-3 and BTT-4 were evaluated for analgesic, anti-inflammatory and anti-arthritic activity. Analgesic and anti-inflammatory activity was evaluated using hot plate test, formalin-induced paw licking test and formalin-induced paw edema test respectively. Complete fruend’s adjuvant (CFA) -induced arthritis model was used for anti-arthritic activity. All test drugs showed significant analgesic activity by increasing the reaction latency time in hot plate test and decreasing the number of lickings in formalin test. BTT-3 was found to be effective in both early and late phase, while all other test drugs were found to be effective only in late phase of nociception. In anti-inflammatory studies, the BTT-3 (25 and 50 mg/kg, i.p.) had significantly reduced the formalin-induced paw edema. In CFA-induced arthritis models, the BTT-3 has showed activity from the 4th day of the treatment, while all the other test drugs have showed significant inhibition of CFA-induced paw edema from the 7th day of the treatment by decreasing the elevated levels of WBC, % Hb, ESR, along with decreasing the serum levels of C-reactive protein (CRP) and rheumatoid factor (RF). In conclusion, all test drugs were found to possess very good analgesic, anti-inflammatory and anti-arthritic activity and BTT-3 was found to be more potent compared to other compounds.