Effects of Coenzyme Q10 on Hemoglobin A1C, Serum Urea and Creatinine in Alloxan-Induced Type 1 Diabetic Rats

Coenzyme Q10 is a natural antioxidant and free radicals scavenger. In the present study, we examined effect of coenzyme Q10 on hemoglobin A1C, serum urea and creatinine in alloxan-induced Type 1 diabetic rats. Thirty Sprage-Dawley male rats were divided into three groups randomly; group one as control, group two diabetic untreatment, and group three treatments with coenzyme Q10 (15 mg/kg i.p daily), respectively. Diabetes was induced in the second and third groups by alloxan injection subcutaneously. After 8 weeks, animals were anaesthetized; blood samples were collected to measure the hemoglobin A1C, serum glucose, urea and creatinine. Coenzyme Q10 significantly decreased hemoglobin A1C, serum glucose, urea and creatinine. Coenzyme Q10 exerts beneficial effects on the hemoglobin A1C and serum glucose in alloxan-induced type 1 diabetic rats.