Title of article
Studies of Cytotoxic Potential of Aqueous Fruit Extract of Cucumis melo.Linn in Prostate Cancer Cell lines PC-3 Using MTT and Neutral Red Assay
Author/Authors
ITTIYAVIRAH, SIBI P Department of Pharmacology - University College of Pharmacy - Cheruvandoor campus, Kottayam, India , GEORGE, ANN Department of Pharmacology - University College of Pharmacy - Cheruvandoor campus, Kottayam, India , SANTHOSH, ANJU M. Department of Pharmacology - University College of Pharmacy - Cheruvandoor campus, Kottayam, India , KURIAN, SUDHI T. Department of Pharmacology - University College of Pharmacy - Cheruvandoor campus, Kottayam, India , PAPPACHAN, PRINSY Department of Pharmacology - University College of Pharmacy - Cheruvandoor campus, Kottayam, India , JACOB, GIFTY Department of Pharmacology - University College of Pharmacy - Cheruvandoor campus, Kottayam, India
Pages
7
From page
19
To page
25
Abstract
The objective of the study was to evaluate the cytotoxic effects of aqueous extract of Cucumis melo fruit
on human prostate cancer cell line (PC-3) using MTT and neutral red assays. The crude aqueous extract
of C. melo was prepared by cold maceration method, filtered, concentrated and tested on PC-3 cell line.
Dose-dependent cytotoxic activities were exhibited on human prostate carcinoma PC-3 cell line. As the
dose of the extract increased, the number of viable cells decreased. This confirms the cytotoxic potential
of the fruit of C. melo.
Keywords
Cytotoxicity , MTT assay , Neutral red assay , Human prostate carcinoma cell lines (PC-3) , Cucumis melo
Journal title
Astroparticle Physics
Serial Year
2015
Record number
2414149
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