Author/Authors :
ITTIYAVIRAH, SIBI P Department of Pharmacology - University College of Pharmacy - Cheruvandoor campus, Kottayam, India , GEORGE, ANN Department of Pharmacology - University College of Pharmacy - Cheruvandoor campus, Kottayam, India , SANTHOSH, ANJU M. Department of Pharmacology - University College of Pharmacy - Cheruvandoor campus, Kottayam, India , KURIAN, SUDHI T. Department of Pharmacology - University College of Pharmacy - Cheruvandoor campus, Kottayam, India , PAPPACHAN, PRINSY Department of Pharmacology - University College of Pharmacy - Cheruvandoor campus, Kottayam, India , JACOB, GIFTY Department of Pharmacology - University College of Pharmacy - Cheruvandoor campus, Kottayam, India
Abstract :
The objective of the study was to evaluate the cytotoxic effects of aqueous extract of Cucumis melo fruit
on human prostate cancer cell line (PC-3) using MTT and neutral red assays. The crude aqueous extract
of C. melo was prepared by cold maceration method, filtered, concentrated and tested on PC-3 cell line.
Dose-dependent cytotoxic activities were exhibited on human prostate carcinoma PC-3 cell line. As the
dose of the extract increased, the number of viable cells decreased. This confirms the cytotoxic potential
of the fruit of C. melo.
Keywords :
Cytotoxicity , MTT assay , Neutral red assay , Human prostate carcinoma cell lines (PC-3) , Cucumis melo
