Synthesis of Novel Amino-Coated Fe3O4 Magnetic Nanoparticle Functionalized with Ciprofloxacin (AFFe3O4- NP@cpf) and Study of Its Effect on Cu(II) and Ni(II) Adsorption

Ciprofloxacin (1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1- piperazinyl) - 3-quinoline carboxylic acid, cpfH) is a member of synthetic antibacterial agent widely used in clinical practice for the treatment of various gram negative and positive microorganisms. In concurrent use of ciprofloxacin with cations, they may bind together and result to formation complex by chelating. Formation of chelates ultimately reduces drug adsorption from the gastrointestinal tract. So, it is recommended a minimum of 2-hour interval between usage of ciprofloxacin and compounds containing cations. The aim of this study was to develop a novel amino-coated magnetic nanoparticle Fe3O4 functionalized by ciprofloxacin (AF-Fe3O4-NP@cpf) to study the amount of cation which adsorbed on ciprofloxacin by Atomic Absorption Spectrophotometry (AAS). The synthesized AF-Fe3O4-NP@cpf was characterized using FT-IR, VSM and TEM. Separation of the adsorbed elements from reactive environment was fascinated with the aid of a magnet. The amount of residual metal in the solution was measured by AAS. Moreover our study investigated the effects of various conditions, such as pH, amount of nanoparticle and contact time of drug and metal in complex formation. The optimal condition of Cu(II) and Ni(II) absorbing was obtained.