Isorhamnetin mitigates learning and memory disturbances in streptozotocin-induced diabetic rats

Background and Objective: Diabetes as a metabolic disorder can cause memory and learning impairment. In recent years, the effect of plant extracts on the treatment of diabetes mellitus has been raised. The purpose of this study was to determine the effect of isorhmnetin administration on learning and memory disability in an experimental model of streptozotocin-induced diabetes mellitus in rats. Materials and Methods: In the present study, for inducing diabetes, streptozotocin was administered at a dose of 60 mg/kg (intraperitoneal) in male rats. Intraperitoneal injection of isorhmnetin (10 mg/kg) was performed after induction of diabetes (10 mg/kg) for 12 weeks. Control groups also received relevant doses. Y-maze and passive avoidance tests were used for assessing of learning and memory ability. The serum glucose and body weight were determined before and 12 weeks after diabetic development. Results: Behavior data showed that compared to control rats, alternation percentage in Y-maze task (p < 0.01) and step through latency in the passive avoidance test (p < 0.001) reduced in the diabetic rats. Administration of isorhmnetin to diabetic rats improved alternation percent (p < 0.01) and step through latency in the passive avoidance test (p < 0.001). Conclusion: This study reveals that isorhmnetin administration to diabetic rats attenuates learning and memory impairment.