Author/Authors :
Esfandiary, Mohammad Ali Department of Medical Parasitology and Mycology - School of Public Health - Tehran University of Medical Sciences , Mahmoudi, shahram Department of Medical Parasitology and Mycology - School of Public Health - Tehran University of Medical Sciences , Zanini, farideh Department of Medical Parasitology and Mycology - School of Public Health - Tehran University of Medical Sciences , safara, mahin Department of Medical Parasitology and Mycology - School of Public Health - Tehran University of Medical Sciences , Mahmoudi, mahmoud Department of Epidemiology and Biostatistics - School of Public Health - Tehran University of Medical Sciences , Farasat, Alireza Young Researchers & Elite Club - Pharmaceutical Sciences Branch - Islamic Azad University , Sabokbar, azar Department of Microbiology - Karaj Branch - Islamic Azad University - Karaj , Abbasi, sanaz Department of Microbiology - Karaj Branch - Islamic Azad University - Karaj , Ghahri, mohammad Department of Biological Sciences - College of Sciences - Imam Hussein University - Tehran , Esfandiary, mohammad Amin Faculty of pharmacy - Tehran University of Medical Sciences - Tehran , Kordbache, parivash Department of Medical Parasitology and Mycology - School of Public Health - Tehran University of Medical Sciences
Abstract :
The aim of the present study was to investigate the antifungal activity of Zataria
multiflora essential oil, fluconazole and ciclopirox olamine against 44 non-albicans
Candida isolates from patients with recurrent vulvovaginal candidiasis. A set of C.
glabrata (29 strains), C. krusei (3 stains) and C. patapsilosis (2 strains) were studied
using Clinical and Laboratory Standards Institute (CLSI) broth macrodilution method.
The results revealed that 33 isolates were resistant (MIC=64 μg/ml), 4 isolates were
susceptible (MIC≤ 8 μg/ml) and 7 isolates had dose-dependent susceptibility (MIC= 16,
32 μg/ml) to fluconazole, respectively. With regard to fluconazole, high resistance rate
was observed in C .glabrata and C. krusei. However, ciclopirox olamine was found to
inhibit the growth of all non-albicans Candida species (MIC≤8 μg/ml). In this study,
favorable antifungal activity against non-albicans Candida species was obtained by Z.
multiflora despite having a wide range of MICs (34875-139500 μg/ml). The results
indicated that ciclopirox olamine and Z. multiflora might be promising in the treatment of
recurrent vulvovaginal candidiasis
Keywords :
ciclopirox olamine , fluconazole , non-albicans candida spp , recurrent vulvovaginal candidiasis , Zataria multiflora
