Title of article
Cytotoxic Effect of Some 1, 4-Dihydropyridine Derivatives Containing Nitroimidazole Moiety
Author/Authors
Miri, Ramin Medicinal and Natural Products Chemistry Research Center - Shiraz University of Medical Sciences, Shiraz - Department of Medicinal Chemistry - Faculty of Pharmacy - Shiraz University of Medical Sciences , Javidnia, Katayoun Medicinal and Natural Products Chemistry Research Center - Shiraz University of Medical Sciences, Shiraz - Department of Medicinal Chemistry - Faculty of Pharmacy - Shiraz University of Medical Sciences , Amirghofran, Zahra Department of Immunology - Faculty of Medicine - Shiraz University of Medical Sciences - Medicinal and Natural Products Chemistry Research Center - Shiraz University of Medical Sciences , Salimi, Hossein Medicinal and Natural Products Chemistry Research Center - Shiraz University of Medical Sciences, Shiraz - Department of Medicinal Chemistry - Faculty of Pharmacy - Shiraz University of Medical Sciences , Sabetghadam, Zahra Medicinal and Natural Products Chemistry Research Center - Shiraz University of Medical Sciences, Shiraz - Department of Medicinal Chemistry - Faculty of Pharmacy - Shiraz University of Medical Sciences , Meili, Savis Medicinal and Natural Products Chemistry Research Center - Shiraz University of Medical Sciences, Shiraz - Department of Medicinal Chemistry - Faculty of Pharmacy - Shiraz University of Medical Sciences , Mehdipour, Ahmad Reza Medicinal and Natural Products Chemistry Research Center - Shiraz University of Medical Sciences, Shiraz - Department of Medicinal Chemistry - Faculty of Pharmacy - Shiraz University of Medical Sciences
Pages
7
From page
497
To page
503
Abstract
The 1,4-dihydropyridine (DHP) derivatives are a known class of calcium channel blockers. Some derivatives of DHP showed significant cytotoxicity. It was shown that this effect may not be the result of interaction with Ca2+ channels. In this study, we performed an investigation about the intrinsic cytotoxicity of some derivatives of DHP containing nitroimidazole moiety on their C4 position on four different cancer cell lines (Raji, K562, Fen and HeLa). The result showed that these compounds had moderate-good cytotoxic activity. In addition, QSAR model shows the importance of N atom in cytotoxicity; Ca2+ channels.
Keywords
1, 4-Dihydropyridines , Cytotoxicity , MTT assay , Nitroimidazole
Journal title
Astroparticle Physics
Serial Year
2011
Record number
2414674
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