Author/Authors :
Senthil Kumar, Raju Department of Pharmaceutical Chemistry - Swamy Vivekanandha College of Pharmacy - Tiruchengodu-637 205, Namakkal (Dt) - Tamilnadu, India , Rajkapoor, Balasubramanian Department of Pharmacology - Dayanandha Sagar College of Pharmacy - Bangalore-560 078, India , Perumal, Perumal Department of Pharmaceutical Chemistry - JKK Nataraja College of Pharmacy - Komarapalayam - Namakkal Dt, Tamilnadu, India , Dhanasekaran, Thangavel Department of Pharmaceutical Chemistry - Swamy Vivekanandha College of Pharmacy - Tiruchengodu-637 205, Namakkal (Dt) - Tamilnadu, India , Alvin Jose, Manonmani Department of Pharmaceutical Chemistry - Swamy Vivekanandha College of Pharmacy - Tiruchengodu-637 205, Namakkal (Dt) - Tamilnadu, India , Jothimanivannan, Chennakesavalu Department of Pharmaceutical Chemistry - Swamy Vivekanandha College of Pharmacy - Tiruchengodu-637 205, Namakkal (Dt) - Tamilnadu, India
Abstract :
The antitumor activity of ethanol extract of Prosopis glandulosa Torr. (EPG) was evaluated against Ehrlich ascites carcinoma (EAC) tumor model in Swiss albino mice on dose dependent manner. The activity was assessed using survival time, average increase in body weight, hematological parameters and solid tumor volume. Oral administration of EPG at the dose of 100, 200 and 400 mg/Kg, significantly (p < 0.001) increased the survival time and decreased the average body weight of the tumor bearing mice. After 14 days of inoculation, EPG was able to reverse the changes in the hematological parameters, protein and PCV consequent to tumor inoculation. Oral administration of EPG was effective in reducing solid tumor mass development induced by EAC cells. The results indicate that EPG possess significant antitumor activity on dose dependent manner.
Keywords :
Prosopis glandulosa , Ehrlich Ascites Carcinoma , Life Span , Hematological Parameters , Solid tumor
