Title of article
Effect of Pimpinella tirupatiensis on Oxidative Enzymes in STZ-induced Diabetic Rat Kidney
Author/Authors
Rajeswara Reddy, Saddala Division of Molecular Biology and Exercise Physiology - Department of Zoology - Sri Venkateswara University -Tirupati-517502, A.P. India. - Department of Biotechnology School of Herbal Studies and Naturo Sciences Dravidian University Kuppam , Lavany, Thopireddy Division of Molecular Biology and Exercise Physiology - Department of Zoology - Sri Venkateswara University - Tirupati-517502, A.P. India , Narasimhulu, Ganapathi Division of Molecular Biology and Exercise Physiology - Department of Zoology - Sri Venkateswara University - Tirupati-517502, A.P. India , Sathyavelu Reddy, Kesireddy Division of Molecular Biology and Exercise Physiology - Department of Zoology - Sri Venkateswara University - Tirupati-517502, A.P. India
Pages
10
From page
277
To page
286
Abstract
The present study was aimed to evaluate the therapeutic potential of Pimpinella tirupatiensis (Pt) by assaying the activities of selective mitochondrial enzymes in streptozotocin induced diabetic rats. Diabetic rats showed a significant (p < 0.01) reduction in the activities of oxidative enzymes Succinate dehydrogenase (SDH), Malate dehydrogenase (MDH), Glutamate dehydrogenase (GDH) and isocitrate dehydrogenase (ICDH). Lactate dehydrogenase (LDH) activity was significantly (p < 0.01) increased in diabetic rats. The daily oral treatment of Pimpinella tirupatiensis ethyl alcohol extract (750 mg/kg body weight/day) to diabetic rats for 30 days reversed the above changes in a significant (p < 0.01) manner. From our observations, we conclude that administration of Pt altered the activities of oxidative enzymes, thereby suggesting its role in mitochondrial energy production. The obtained results were compared with Glibenclamide, a standard anti diabetic drug. Thus, the modulatory effects of Pt on altering these enzymes activities afford a promise for widespread use for treatment of diabetes in the future.
Keywords
Pimpinella tirupatiensis , Diabetes , Mitochondrial enzymes , Oxidative stress
Journal title
Astroparticle Physics
Serial Year
2012
Record number
2414726
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