Title of article :
Effect of Pimpinella tirupatiensis on Oxidative Enzymes in STZ-induced Diabetic Rat Kidney
Author/Authors :
Rajeswara Reddy, Saddala Division of Molecular Biology and Exercise Physiology - Department of Zoology - Sri Venkateswara University -Tirupati-517502, A.P. India. - Department of Biotechnology School of Herbal Studies and Naturo Sciences Dravidian University Kuppam , Lavany, Thopireddy Division of Molecular Biology and Exercise Physiology - Department of Zoology - Sri Venkateswara University - Tirupati-517502, A.P. India , Narasimhulu, Ganapathi Division of Molecular Biology and Exercise Physiology - Department of Zoology - Sri Venkateswara University - Tirupati-517502, A.P. India , Sathyavelu Reddy, Kesireddy Division of Molecular Biology and Exercise Physiology - Department of Zoology - Sri Venkateswara University - Tirupati-517502, A.P. India
Abstract :
The present study was aimed to evaluate the therapeutic potential of Pimpinella tirupatiensis (Pt) by assaying the activities of selective mitochondrial enzymes in streptozotocin induced diabetic rats. Diabetic rats showed a significant (p < 0.01) reduction in the activities of oxidative enzymes Succinate dehydrogenase (SDH), Malate dehydrogenase (MDH), Glutamate dehydrogenase (GDH) and isocitrate dehydrogenase (ICDH). Lactate dehydrogenase (LDH) activity was significantly (p < 0.01) increased in diabetic rats. The daily oral treatment of Pimpinella tirupatiensis ethyl alcohol extract (750 mg/kg body weight/day) to diabetic rats for 30 days reversed the above changes in a significant (p < 0.01) manner. From our observations, we conclude that administration of Pt altered the activities of oxidative enzymes, thereby suggesting its role in mitochondrial energy production. The obtained results were compared with Glibenclamide, a standard anti diabetic drug. Thus, the modulatory effects of Pt on altering these enzymes activities afford a promise for widespread use for treatment of diabetes in the future.
Keywords :
Pimpinella tirupatiensis , Diabetes , Mitochondrial enzymes , Oxidative stress
Journal title :
Astroparticle Physics
