Title of article :
Labdane-Type Diterpene and Two Flavones from Salvia Sharifii Rech. f. and Esfan. and their Biological Activities
Author/Authors :
Farjam, Mohammad Hossein Department of Chemistry - Firoozabad Branch - Islamic Azad University, Firoozabad , Rustaiyan, Abdolhossein Department of Chemistry - Science and Research Branch - Islamic Azad University, Tehran , Ezzatzadeh, Elham Department of Chemistry - Ardabil Branch - Islamic Azad University, Ardabil , Jassbi, Amir Reza Medicinal and Natural Products Chemistry Research Canter - Shiraz University of Medicinal Sciences
Abstract :
Two flavones, ladanein and 6-hydroxy-5,7,4′-trimethoxyflavone and one labdane-type
diterpene, ent-13-epi-manoyloxide, were isolated from an ethyl acetate-methanol extract of the aerial parts of Salvia sharifii. The compounds were purified using several chromatographic methods. Structural elucidation of the compounds was performed using their 1H and 13C-NMR data, EI mass and UV spectral data. The compounds have been subjected to antimicrobial, antioxidant and cytotoxic activity. The diterpene showed higher cytotoxic activity than the flavones while the later compounds were better antioxidants compared with the isolated diterpene.
Keywords :
TLadanein , 6-hydroxy-5,7,4′-trimethoxyflavone , Ent-13-epi-manoyloxide , Antioxidant , Antimicrobial , Cytotoxic
Journal title :
Astroparticle Physics
