Author/Authors :
Peng, Xiahui Department of Bioengineering and Environmental Science - Changsha University - Changsha 410003, China , Zhuang, Qiang School of Chemistry and Chemical Engineering - Central South University - Changsha 410083, China , Peng, Dongming School of Pharmacy - Hunan University of Chinese Medicine - Changsha 410208, China , Dong, Qiuli School of Chemistry and Chemical Engineering - Central South University - Changsha 410083, China , Tan, Lini School of Chemistry and Chemical Engineering - Central South University - Changsha 410083, China , Jiao, Feipeng School of Chemistry and Chemical Engineering - Central South University - Changsha 410083, China , Liu, Linqi Department of Bioengineering and Environmental Science - Changsha University - Changsha 410003, China , Liu, jingyu Department of Bioengineering and Environmental Science - Changsha University - Changsha 410003, China , Zhao, Chenxi Department of Bioengineering and Environmental Science - Changsha University - Changsha 410003, China , Wang, Xiaomei Department of Bioengineering and Environmental Science - Changsha University - Changsha 410003, China
Abstract :
In this paper, carbon nanotubes (CNTs) were added into chitosan (CS) hydrogels in the form of chitosan modified CNTs (CS-CNTs) composites to prepare carbon nanotubes hydrogels (CNTs-GEL). The products, named CS-MWCNTs, were characterized by scanning electron microscope (SEM) and Fourier transform infrared (FTIR) spectroscopy. Swelling properties and effect of pH on controlled release performance of the two kinds of hydrogels, CNTs- GEL and pure chitosan hydrogels without CNTs (GEL), were investigated respectively. The results showed that CNTs-GEL possess better controlled release performance than GEL. The releasing equilibrium time of CNTs-GEL was longer than that of GEL in both pH = w7.4 and
pH=1.2 conditions, although the release ratios of the model drug are similar in the same pH buffer solutions. It is found that release kinetics is better fitted Ritger-Peppas empirical model indicating a fick-diffusion process in pH = 1.2, while in pH = 7.4 it was non-fick diffusion involving surface diffusion and corrosion diffusion processes.
Keywords :
Chitosan , Drug delivery , Hydrogel , Multi-walled carbon nanotubes , Release kinetics
