Title of article :
Immune-Regulatory Events in the Clearance of HBsAg in Chronic Hepatitis B: Focuses on HLA-DP
Author/Authors :
Mohamadkhani, Ashraf Liver and Pancreatobiliary Diseases Research Center - Digestive Diseases Research Institute - Tehran University of Medical Sciences , Katoonizadeh, Aezam Liver and Pancreatobiliary Diseases Research Center - Digestive Diseases Research Institute - Tehran University of Medical Sciences , Poustchi, Hossein Liver and Pancreatobiliary Diseases Research Center - Digestive Diseases Research Institute - Tehran University of Medical Sciences
Abstract :
Successful clearance of hepatitis B virus (HBV) is a promising event in
which host’s immune system will attempt to get rid of the virus. The immunological
events of HBsAg seroclearance have attracted great attention in both
natural history investigations and therapeutic trials. Recent genome-wide association
studies (GWAS) has confirmed polymorphisms in the human leukocyte
antigen (HLA)-DP locus associated with spontaneous HBV clearance. In this
review the impact of host immune response in declining HBsAg during the
natural history of the infection has been discussed.
Keywords :
Human leukocyte antigens DP (HLA-DP) , Polymorphism , Immune response , Chronic hepatitis B
Journal title :
Astroparticle Physics
