Author/Authors :
Farzanehfar, Vahid Department of Pharmacology and Toxicology - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Faizi, Mehrdad Department of Pharmacology and Toxicology - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Naderi, Nima Department of Pharmacology and Toxicology - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran, Iran , Kobarfard, Farzad Department of Medicinal Chemistry - School of Pharmacy - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract :
Dibutyl phthalate (DBP) is a phthalic acid ester and is widely used in polymeric products to
make them more flexible. DBP is found in almost every plastic material and is believed to be
persistent in the environment. Various analytical methods have been used to measure DBP in
different matrices. Considering the ubiquitous nature of DBP, the most important challenge in
DBP analyses is the contamination of even analytical grade organic solvents with this compound
and lack of availability of a true blank matrix to construct the calibration line. Standard addition
method or using artificial matrices reduce the precision and accuracy of the results. In this study
a surrogate analyte approach that is based on using deuterium labeled analyte (DBP-d4) to
construct the calibration line was applied to determine DBP in hexane samples.
